![]() 38,39 Primary (clonal) and other clinical disorders associated with mast cell activation, as well as other conditions associated with vasoactive mediator release, must be eliminated as possible causes of the clinical findings. These additional criteria include response to antimediator therapy and an increase in a validated urinary or serum marker of mast cell activation (e.g., tryptase) with an episode. ![]() The assumption is that this diagnosis is applied to those who are having episodes caused by release of mediators associated with hyperreactivity of mast cells, which then activate spontaneously.ĭiagnostic criteria have been proposed to separate possible MCAS from other causes of such clinical findings. The term mast cell activation syndrome (MCAS) is sometimes applied as a diagnosis for patients who present with episodic allergy-like signs and symptoms (e.g., flushing, urticaria, diarrhea, wheezing) involving two or more organ systems and in whom an extensive medical evaluation has failed to identify an etiology. Metcalfe, in Middleton's Allergy (Eighth Edition), 2014 Mast Cell Activation Disorder/Syndrome ![]()
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